Gliomas can disrupt the thymus and its immune response.
Can restarting thymic immune response assist in destroying gliomas?
Chimeric models may create an immune response?
Glioma disrupts thymic homeostasis and induces T-cell apoptosis
http://www.ncbi.nlm.nih.gov/pubmed/18392618
http://www.ncbi.nlm.nih.gov/pubmed/12952285
On the International Space Station (ISS) all mice die of premature aging (gray hair and colon cancer) at six months of age. Normal mice live 3-4 yrs on earth.
Immune system compromised during spaceflight, study finds. May 14th, 2010.
http://www.physorg.com/news193046040.html
http://www.ncbi.nlm.nih.gov/pubmed/20213684
http://wrair-www.army.mil/files/Mouse-Immunology-Tissue-Loss-Release.pdf
AIDS patients die of a shrinking thymus.
The Role of the Thymus in HIV Infection: A 10-Year Perspective
http://www.medscape.com/viewarticle/568417
Could rapid aging of mice on the ISS be related to thymus failures similar to AIDS patients?
Could an artificial thymus be used to study the aging of mice and naked mole rats?
What insights could be learned from studying thymus failure in space?
Could we build a model of the aging thymus using an artificial thymus on ISS?http://www.sciencedaily.com/releases/2012/03/120329124605.htm
http://www.cell.com/retrieve/pii/S0092867412002103
Univ. of AZ has built a microarray for thymus:
ISS Thymus Microarray
http://www.ncbi.nlm.nih.gov/pubmed/20213684
http://www.fasebj.org/cgi/reprint/02-0749fjev1.pdf
Can microfluidic chips monitor blood for cancer cells and thymus immune response? Can we store blood from astronauts, AIDS and cancer patients today to monitor cancer progression and chemotherapy efficacy using a cancer and thymus chip combination?
Could naked mole rats be used to model the thymus and immune system in microgravity?
Naked Mole Rats have a robust immune system.
http://en.wikipedia.org/wiki/Naked_mole_rat
Chimeric immune systems may be built using thymus cells from one organism grown in lymph nodes of another. Could mole rat thymus cells be given to mice?
What would be the rejection rates?
http://dartmed.dartmouth.edu/winter05/html/disc_chimeric.php
Humanized mice have been used for cancer research.
http://en.wikipedia.org/wiki/Humanized_mouse
Would a chimeric immune system be possible by injecting Naked Mole Rat thymus cells into mouse or human lymph nodes? Could this extend life for cancer patients, AIDS, mice on ISS?
http://www.sciencedaily.com/releases/2012/09/120927174917.htm
Can microfluidic chips monitor blood for cancer cells and thymus immune response? Can we store blood from astronauts, AIDS and cancer patients today to monitor cancer progression and chemotherapy efficacy using a cancer and thymus chip combination
Could chimeric immune systems be a fast track to saving aging immune systems? Glioma immune response?
What would be the side effects?
